Transcriptional regulation of follicular T-helper (Tfh) cells
نویسندگان
چکیده
منابع مشابه
Impaired Function of CD4+ T Follicular Helper (Tfh) Cells Associated with Hepatocellular Carcinoma Progression
BACKGROUND AND AIMS CD4+ T follicular helper (Tfh) cells, a new subset of immune cells, have been demonstrated to be involved in the development and prognosis of tumors. However, their functional role in human hepatocellular carcinoma (HCC) is relatively unknown, and the detailed mechanisms in HCC development remain to be described. METHODS A total of 85 HCC patients with hepatitis B virus (H...
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T follicular helper (TFH) cells are gatekeepers of the humoral immune response. Without help from this CD4+ T cell subset, B cells cannot differentiate into high-affinity memory B cells and antibody-producing long-lived plasma cells which are the basis of protective immune responses. At the same time, dysregulated TFH cell responses are causative for many autoimmune disorders (reviewed in [1])....
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2013
ISSN: 0105-2896
DOI: 10.1111/imr.12040